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574791

Sigma-Aldrich

Hydroxyapatite

synthetic, 99.8% trace metals basis (excludes Mg)

Synonym(s):

Calcium phosphate tribasic, Calcium hydroxyphosphate, HAp, Hydroxylapatite, Tribasic calcium phosphate

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About This Item

Linear Formula:
[Ca5(OH)(PO4)3]x
CAS Number:
12167-74-7
Molecular Weight:
502.31
EC Number:
235-330-6
MDL number:
MFCD00010904
UNSPSC Code:
12352302
PubChem Substance ID:
24880760
NACRES:
NA.23

Quality Level

100

Assay

99.8% trace metals basis (excludes Mg)

form

solid

impurities

≤2500 ppm Trace Metal Analysis

mp

1100 °C (lit.)

SMILES string

[Ca++].[Ca++].[Ca++].[Ca++].O[Ca+].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O

InChI

1S/5Ca.3H3O4P.H2O/c;;;;;3*1-5(2,3)4;/h;;;;;3*(H3,1,2,3,4);1H2/q5*+2;;;;/p-10

InChI key

XYJRXVWERLGGKC-UHFFFAOYSA-D

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Related Categories

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Xi Chen et al.
The Journal of biological chemistry, 289(16), 11162-11174 (2014-03-13)
Calcium phosphate precipitates (CPPs) form complexes with DNA, which enter cells via endocytosis. Under this condition CPPs induce autophagy via the canonic autophagy machinery. Here we showed that CPP-induced autophagy was also dependent on endocytosis as the process was significantly
Liam M Grover et al.
Biomaterials, 34(28), 6631-6637 (2013-06-12)
Pyrophosphate ions are both inhibitors of HA formation and substrates for phosphatase enzymes. Unlike polyphosphates their hydrolysis results simultaneously in the complete loss of mineral formation inhibition and a localised elevation in orthophosphate ion concentration. Despite recent advances in our
Thomas Lyon et al.
The Journal of bone and joint surgery. American volume, 95(23), 2088-2096 (2013-12-07)
Recombinant human bone morphogenetic protein-2 (rhBMP-2) applied on an absorbable collagen sponge improves open tibial fracture-healing as an adjunct to unreamed intramedullary nail fixation. We evaluated rhBMP-2 and a new, injectable calcium phosphate matrix (CPM) formulation in acute closed tibial
Tie Liu et al.
Bone, 56(1), 110-118 (2013-06-05)
As an alternative to an autologous bone graft, deproteinized bovine bone (DBB) is widely used in the clinical dentistry. Although DBB provides an osteoconductive scaffold, it is not capable of enhancing bone regeneration because it is not osteoinductive. In order
Ehud Segal et al.
PloS one, 4(4), e5233-e5233 (2009-04-22)
There is an immense clinical need for novel therapeutics for the treatment of angiogenesis-dependent calcified neoplasms such as osteosarcomas and bone metastases. We developed a new therapeutic strategy to target bone metastases and calcified neoplasms using combined polymer-bound angiogenesis inhibitors.
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