- Riding the DUBway: regulation of protein trafficking by deubiquitylating enzymes.
Riding the DUBway: regulation of protein trafficking by deubiquitylating enzymes.
The Journal of cell biology (2006-05-17)
Susan M Millard, Stephen A Wood
PMID16702236
ABSTRACT
Ubiquitylation is a key regulator of protein trafficking, and much about the functions of ubiquitin ligases, which add ubiquitin to substrates in this regulation, has recently come to light. However, a clear understanding of ubiquitin-dependent protein localization cannot be achieved without knowledge of the role of deubiquitylating enzymes (DUBs). DUBs, by definition, function downstream in ubiquitin pathways and, as such, have the potential to be the final editors of protein ubiquitylation status, thus determining substrate fate. This paper assimilates the current evidence concerning the substrates and activities of DUBs that regulate protein trafficking.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
MISSION® shRNA Human Gene Family Set, Lentiviral Particles, Ubiquitin Hydrolases (DUBS)
Sigma-Aldrich
MISSION® shRNA Human Gene Family Set, Bacterial Glycerol Stock, Ubiquitin Hydrolases (DUBS)