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  • Palladium-catalyzed α-arylation of 2-chloroacetates and 2-chloroacetamides.

Palladium-catalyzed α-arylation of 2-chloroacetates and 2-chloroacetamides.

The Journal of organic chemistry (2013-04-11)
Gary A Molander, Kaitlin M Traister, Thiago Barcellos
ABSTRACT

A method has been developed for the Pd-catalyzed synthesis of α-(hetero)aryl esters and amides through a Suzuki-Miyaura cross-coupling reaction. This method avoids the use of strong base, does not necessitate inert or low temperature formation of reagents, and does not require the use of a large excess of organometallic reagent. Utilization of organotrifluoroborate salts as nucleophilic partners allows a variety of functional groups and heterocyclic compounds to be tolerated.

MATERIALS
Product Number
Brand
Product Description

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