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  • Palladium-catalyzed double carbonylation using near stoichiometric carbon monoxide: expedient access to substituted 13C2-labeled phenethylamines.

Palladium-catalyzed double carbonylation using near stoichiometric carbon monoxide: expedient access to substituted 13C2-labeled phenethylamines.

The Journal of organic chemistry (2012-06-26)
Dennis U Nielsen, Karoline Neumann, Rolf H Taaning, Anders T Lindhardt, Amalie Modvig, Troels Skrydstrup
ABSTRACT

A novel and general approach for (13)C(2)- and (2)H-labeled phenethylamine derivatives has been developed, based on a highly convergent single-step assembly of the carbon skeleton. The efficient incorporation of two carbon-13 isotopes into phenethylamines was accomplished using a palladium-catalyzed double carbonylation of aryl iodides with near stoichiometric carbon monoxide.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
9-Methyl-9H-fluorene-9-carbonyl-13C chloride, ≥97.0% (GC)
Sigma-Aldrich
9-Methyl-9H-fluorene-9-carbonyl chloride, ≥99.0% (GC)