Anhydroecgonine methyl ester, or methylecgonidine, is a metabolite of smoked crack cocaine. This cocaine analog is also used as an ingredient in the production of phenyltropanes, a class of drugs used to treat cocaine dependency. This certified solution standard is suitable for use in LC/MS or GC/MS applications for urine drug testing, clinical toxicology, or forensic analysis.
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During the smoking of crack cocaine (COC), methyl ecgonidine (MED) is formed as one of the pyrolysis products. Once in the body, MED is converted to ecgonidine (ED) through several processes that include spontaneous hydrolysis and enzymatic hydrolysis. The presence
Journal of mass spectrometry : JMS, 37(5), 525-532 (2002-07-12)
Cocaine is transformed into hepatotoxic metabolites through oxidative pathways. For anhydroecgonine methyl ester (AEME), the main constituent in crack smoke, the oxidative metabolism has not been studied. Therefore, incubation of AEME with rat liver microsomes was performed and a metabolite
British journal of pharmacology, 135(1), 188-196 (2002-01-12)
1. In the present experiments, we investigated the effects of methylecgonidine (MEG) on nitric oxide (NO) production in cultured neonatal rat cardiomyocytes. Incubation of cultured cardiomyocytes with carbachol or MEG for 48 h significantly enhanced NO production. No release was
