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402184

Sigma-Aldrich

6-Chloro-3-formyl-7-methylchromone

98%

Synonym(s):

6-Chloro-7-methyl-4-oxo-4H-1-benzopyran-3-carboxaldehyde

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About This Item

Empirical Formula (Hill Notation):
C11H7ClO3
CAS Number:
64481-12-5
Molecular Weight:
222.62
MDL number:
MFCD00191919
UNSPSC Code:
12352100
PubChem Substance ID:
24865058
NACRES:
NA.22

Assay

98%

mp

183-185 °C (lit.)

SMILES string

Cc1cc2OC=C(C=O)C(=O)c2cc1Cl

InChI

1S/C11H7ClO3/c1-6-2-10-8(3-9(6)12)11(14)7(4-13)5-15-10/h2-5H,1H3

InChI key

NULJNFUEBPQUNB-UHFFFAOYSA-N

Gene Information

human ... PTPN1(5770)

General description

6-Chloro-3-formyl-7-methylchromone (6-Chloro-7-methyl-4-oxo-4H-1-benzopyran-3-carboxaldehyde) is a benzopyran derivative. It is a bicyclic heterocyclic molecule made up of a benzene ring fused to a heterocyclic pyran ring.

Application

6-Chloro-3-formyl-7-methylchromone is the suitable reagent used in a study to investigate the multidrug resistabnce reversal by some 3- formylchromones in human colon cancer and mouse lymphoma cells transfected with the human MDR1 gene. It is the suitable reagent used in the synthesis of uridine-based library.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Howard C Hang et al.
Chemistry & biology, 11(3), 337-345 (2004-05-05)
The polypeptide N-acetyl-alpha-galactosaminyltransferases (ppGalNAcTs, also abbreviated ppGaNTases) initiate mucin-type O-linked glycosylation and therefore play pivotal roles in cell-cell communication and protection of tissues. In order to develop new tools for studying mucin-type O-linked glycosylation, we screened a 1338 member uridine-based
Zoltán Baráth et al.
In vivo (Athens, Greece), 20(5), 645-649 (2006-11-10)
Several new 3-formylchromone derivatives proved to be modifiers of multidrug resistance in mouse lymphoma cells and in human Colo320 colon cancer cells. There is apparently a structure-activity relationship between the antiproliferative multidrug resistance-reversing effect and the chemical structure of the
Juan Zhang et al.
The Analyst, 140(16), 5716-5723 (2015-07-15)
Inhibitors of protein tyrosine phosphatase 1B (PTP1B) are promising agents for the treatment of type 2 diabetes and obesity, so a colorimetric method has been developed in this work for PTP1B assay and screening of its inhibitors. The method is

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