- A formal total synthesis of taxol aided by an automated synthesizer.
A formal total synthesis of taxol aided by an automated synthesizer.
Chemistry, an Asian journal (2007-04-19)
Takayuki Doi, Shinichiro Fuse, Shigeru Miyamoto, Kazuoki Nakai, Daisuke Sasuga, Takashi Takahashi
PMID17441074
ABSTRACT
A 36-step synthesis was carried out in automated synthesizers to provide a synthetic key intermediate of taxol. A key step involved a microwave-assisted alkylation reaction to construct the ABC ring system from an AC precursor. Subsequent formation of the D ring afforded baccatin III, a well-known precursor of taxol.
MATERIALS