- Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase.
Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase.
Bioorganic & medicinal chemistry letters (2010-08-31)
Joris W De Schutter, Serge Zaretsky, Sarah Welbourn, Arnim Pause, Youla S Tsantrizos
PMID20801032
ABSTRACT
A structure-based approach was pursued in designing novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase (hFPPS). Preliminary SAR and structural evidence for the simultaneous binding of these inhibitors into the isopentenyl pyrophosphate (IPP) and the geranyl pyrophosphate (GPP) substrate sub-pockets of the enzyme are presented.
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Geranyl pyrophosphate ammonium salt, 1 mg/mL in methanol (:aqueous 10 mM NH4OH (7:3)), ≥95% (TLC)
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