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D5172

Sigma-Aldrich

n-Dodecyl β-D-maltoside

BioXtra, ≥98% (GC)

Synonym(s):

DDM, Lauryl-β-D-maltoside

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About This Item

Empirical Formula (Hill Notation):
C24H46O11
CAS Number:
Molecular Weight:
510.62
Beilstein:
55318
MDL number:
UNSPSC Code:
12161900
eCl@ss:
32190102
PubChem Substance ID:
NACRES:
NA.25

description

non-ionic

product line

BioXtra

Assay

≥98% (GC)

form

powder

mol wt

micellar avg mol wt 50,000

aggregation number

98

technique(s)

protein purification: suitable
protein quantification: suitable

impurities

≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter

ign. residue

≤0.1%

CMC

0.15 mM (20-25°C)

mp

224-226 °C (lit.)

anion traces

chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%
Ca: ≤0.001%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.0005%

storage temp.

−20°C

SMILES string

CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O

InChI

1S/C24H46O11/c1-2-3-4-5-6-7-8-9-10-11-12-32-23-21(31)19(29)22(16(14-26)34-23)35-24-20(30)18(28)17(27)15(13-25)33-24/h15-31H,2-14H2,1H3/t15-,16-,17-,18+,19-,20-,21-,22-,23-,24-/m1/s1

InChI key

NLEBIOOXCVAHBD-QKMCSOCLSA-N

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General description

n-Dodecyl β-D-maltoside is a non-ionic surfactant belonging to the alkyl polyglucoside family.

Application

Non-ionic detergent for the stabilization and activation of enzymes and for membrane research.
n-Dodecyl β-D-maltoside has been used in a study to assess the effect of detergents on the thermal behavior of elastin-like polypeptides (ELP). It has also been used in a study to investigate how membrane structures will respond to detergent solubilization from amino acid sequences.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Effect of detergents on the thermal behavior of elastin-like polypeptides
Thapa, A.
Biopolymers, 99, 55-55 (2012)
Rotational Diffusion of Coumarin 153 in Nanoscopic Micellar Environments of n-dodecyl-β-D-maltoside and n-dodecyl-hexaethylene-glycol Mixtures
Hierrezuelo, H. and C. Ruiz
The Journal of Physical Chemistry, 116, 12476-12476 (2012)
Antonello Calcutta et al.
Biochimica et biophysica acta, 1818(9), 2290-2301 (2012-04-25)
Membrane proteins are vital for biological function, and their action is governed by structural properties critically depending on their interactions with the membranes. This has motivated considerable interest in studies of membrane protein folding and unfolding. Here the structural changes
Vincent G Nadeau et al.
Biochemistry, 51(31), 6228-6237 (2012-07-12)
The ability to predict from amino acid sequence how membrane protein structures will respond to detergent solubilization would significantly facilitate experimental characterization of these molecules. Here we have investigated and compared the response to solubilization by the "mild" n-dodecyl-β-D-maltoside (DDM)
Stephen B Long et al.
Science (New York, N.Y.), 309(5736), 897-903 (2005-07-09)
Voltage-dependent potassium ion (K+) channels (Kv channels) conduct K+ ions across the cell membrane in response to changes in the membrane voltage, thereby regulating neuronal excitability by modulating the shape and frequency of action potentials. Here we report the crystal

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