A8727

Antalarmin hydrochloride

≥98% (HPLC), solid, CRF1 antagonist

• Synonym(s): N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolol[2,3-d]pyrimidin-4-amine hydrochloride
• Empirical Formula (Hill Notation): C₂₄H₃₄N₄·HCl
• CAS Number: 220953-69-5
• Molecular Weight: 415.01
• MDL number: MFCD05664721
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724401
• NACRES: NA.77

Properties

• product name: Antalarmin hydrochloride, ≥98% (HPLC), solid
• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: off-white
• solubility: DMSO: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl[H].CCCCN(CC)c1nc(C)nc2n(c(C)c(C)c12)-c3c(C)cc(C)cc3C
• InChI: 1S/C24H34N4.ClH/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5;/h13-14H,9-12H2,1-8H3;1H
• InChI key: CGDGXEDXEXACKQ-UHFFFAOYSA-N

Description

Application

Antalarmin hydrochloride has been used:

• to study its effect on stress-induced tryptophan hydroxylase 2 activity
• to study the anxiogenic effects of corticotropin-releasing factor 1 (CRF1) activation
• to analyze the therapeutic effect of blocking corticotrophin-releasing hormone (CRH) signaling in treating social stress-induced depression

Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.

Biochem/physiol Actions

Antalarmin serves as a non steroidal inhibitor of pregnancy even during the early stages. It is known to delay parturition. It also prevents the development of gastric ulcers which arises in response to stress.

Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.

Features and Benefits

This compound is featured on the Corticotropin-Releasing Factor Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves