Skip to Content
Merck
All Photos(1)

Key Documents

567028

Sigma-Aldrich

SIN-1 hydrochloride

≥98% (HPLC), solid, nitric oxide (NO) donor, Calbiochem®

Synonym(s):

SIN-1, Hydrochloride, 3-Morpholinosydnonimine, HCl

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C6H10N4O2 · xHCl
CAS Number:
16142-27-1
Molecular Weight:
170.17 (free base basis)
MDL number:
MFCD00214332
UNSPSC Code:
12352200
NACRES:
NA.77

product name

SIN-1, Hydrochloride, Nitric oxide (NO) donor.

Quality Level

100

Assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

DMSO: 10 mg/mL
ethanol: 10 mg/mL
water: 25 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C6H11N4O2.ClH/c7-6-5-10(8-12-6)9-1-3-11-4-2-9;/h5H,1-4,7H2;1H/q+1;/p-1

InChI key

ZRFWHHCXSSACAW-UHFFFAOYSA-M

General description

Nitric oxide (NO) donor. Spontaneously decomposes to yield NO and superoxide anion radicals. Also inhibits the release of plasminogen activator inhibitor (PAI) from stimulated platelets.
Nitric oxide (NO) donor. Spontaneously decomposes to yield NO and superoxide anion radicals. Also inhibits the release of plasminogen activator inhibitor (PAI) from stimulated platelets. Unstable in aqueous solution.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Nitric oxide (NO) donor
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Harmful (C)

Reconstitution

Unstable in aqueous solution; reconstitute just prior to use. Following reconstitution, aliquot and freeze (-20°C).





From Catalog:

Desc. Field- added "Unstable in aqueous solution."

Other Notes

Gow, A.J., et al. 2000. Am. J. Physiol. 278, C1099.
Gergel, D., et al. 1995. J. Biol. Chem.270, 20922.
de Groot, H., et al. 1993. FEBS Lett.315, 139.
Lipton, S.A., et al. 1993. Nature364, 626.
Drummer, C., et al. 1991. Thromb. Res.63, 553.
Omar, B.A., et al. 1990. Free Radical Biol. Med.9, 465

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Panagiotis F Christopoulos et al.
Antioxidants (Basel, Switzerland), 10(7) (2021-08-07)
Metabolic modulation of macrophage activation has emerged as a promising strategy lately in immunotherapeutics. However, macrophages have a broad spectrum of functions and thus, understanding the exact metabolic changes that drive a particular immune response, is of major importance. In
Sarah McCarrick et al.
International journal of nanomedicine, 16, 5895-5908 (2021-09-04)
Gold nanoparticles (AuNPs) have the potential to be used in various biomedical applications, partly due to the inertness and stability of gold. Upon intravenous injection, the NPs interact with the mononuclear phagocyte system, first with monocytes in the blood and

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service