564494

4-Fluoro-2-methoxyphenylboronic acid

≥95%

• Synonym(s): 4-Fluoro-2-methoxybenzeneboronic acid
• Linear Formula: FC₆H₃(OCH₃)B(OH)₂
• CAS Number: 179899-07-1
• Molecular Weight: 169.95
• MDL number: MFCD03788423
• UNSPSC Code: 12352103
• PubChem Substance ID: 24880183
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: ≥95%
• form: powder
• mp: 131-136 °C (lit.)
• functional group: fluoro
• SMILES string: COc1cc(F)ccc1B(O)O
• InChI: 1S/C7H8BFO3/c1-12-7-4-5(9)2-3-6(7)8(10)11/h2-4,10-11H,1H3
• InChI key: ADJBXDCXYMCCAD-UHFFFAOYSA-N

Description

Application

Reactant involved in:

• Suzuki-Miyaura cross-coupling reactions for synthesis of heterobiaryls
• Suzuki and Still coupling for synthesis of antithrombotic drugs

Reactant / precursor used for the synthesis of biologically active molecules including:

• 2-(4-pyridyl)thienopyridinones for use as GSK-3β inhibitors
• Arylheteroarylmethylamines as NR2B subtype of NMDA receptor antagonists with antidepressant activity
• Biphenylketones for use as dual modulators of inflammation and bone loss
• CB1 antagonists

Other Notes

Contains varying amounts of anhydride

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves