Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Cancer letters (2012-10-04)

Himashinie V K Diyabalanage, Michael L Granda, Jacob M Hooker

ABSTRACT

One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of well-tolerated doses of HDACis to platinum-based chemotherapeutics has been proven in vitro and in vivo in recent studies for many cancer types and stages. In this review, we discuss the most commonly used combinations of histone deacetylase inhibitors and platinum based drugs in the context of their possible mechanisms, efficiency, efficacy, and related drawbacks in preclinical and clinical studies.

MATERIALS

Product Number

Brand

Product Description

444685

Sigma-Aldrich

Platinum, wire, diam. 2.0 mm, 99.9% trace metals basis

357375

Sigma-Aldrich

Platinum, wire, diam. 0.076 mm, ≥99.99% trace metals basis

349348

Sigma-Aldrich

Platinum, foil, thickness 0.127 mm, 99.99% trace metals basis

349380

Sigma-Aldrich

Platinum, foil, thickness 0.1 mm, 99.9% trace metals basis

349321

Sigma-Aldrich

Platinum, foil, thickness 0.25 mm, 99.99% trace metals basis

349402

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, 99.9% trace metals basis

520780

Sigma-Aldrich

Platinum black, fuel cell grade, ≥99.9% trace metals basis

267244

Sigma-Aldrich

Platinum, foil, thickness 0.025 mm, 99.9% trace metals basis

205915

Sigma-Aldrich

Platinum black, black, powder, ≤20 μm, ≥99.95% trace metals basis

267821

Sigma-Aldrich

Platinum, wire, diam. 0.127 mm, 99.9% trace metals basis

298093

Sigma-Aldrich

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520799

Sigma-Aldrich

Platinum black, low bulk density, ≥99.9% trace metals basis

327484

Sigma-Aldrich

Platinum, shot, ≤3 mm, ≥99.9% trace metals basis

GF41718258

Platinum, wire reel, 5m, diameter 0.05mm, hard, 99.99%

GF33625683

Platinum, wire, straight, 200mm, diameter 0.1mm, hard, 99.99%

GF21655504

Platinum, wire reel, 5m, diameter 0.063mm, hard, 99.9%

GF58265488

Platinum, foil, not light tested, 50x50mm, thickness 0.004mm, as rolled, 99.95%

GF60973791

Platinum, tube, 200mm, outside diameter 1.0mm, inside diameter 0.8mm, wall thickness 0.1mm, as drawn, 99.95%

GF94661657

Platinum, tube, 200mm, outside diameter 1.2mm, inside diameter 1.0mm, wall thickness 0.1mm, as drawn, 99.95%

GF91869227

Platinum, tube, 100mm, outside diameter 0.7mm, inside diameter 0.4mm, wall thickness 0.15mm, as drawn, 99.95%

GF19165552

Platinum, tube, 50mm, outside diameter 1.0mm, inside diameter 0.8mm, wall thickness 0.1mm, as drawn, 99.95%

GF22496328

Platinum, tube, 100mm, outside diameter 0.6mm, inside diameter 0.5mm, wall thickness 0.05mm, as drawn, 99.95%

GF55400666

Platinum, insulated wire, 0.5m, conductor diameter 0.025mm, insulation thickness 0.005mm, polyimide insulation, 99.99%

GF43344581

Platinum, insulated wire, 2m, conductor diameter 0.018mm, insulation thickness 0.002mm, polyester insulation, 99.99%

GF86887793

Platinum, tube, 100mm, outside diameter 1.0mm, inside diameter 0.8mm, wall thickness 0.1mm, as drawn, 99.95%

GF21472141

Platinum, rod, 10mm, diameter 4.0mm, 99.95%

GF58198517

Platinum, wire reel, 0.05m, diameter 0.6mm, as drawn, 99.99+%

GF90827185

Platinum, foil, not light tested, 50x50mm, thickness 0.0125mm, as rolled, 99.95%

GF43288487

Platinum, wire reel, 0.05m, diameter 1.0mm, annealed, may be used as one component of a thermocouple, 99.99%

GF35428406

Platinum, foil, 15x15mm, thickness 0.2mm, as rolled, 99.95%