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Synthesis, characterization, and pharmacological evaluation of novel azolo- and azinothiazinones containing 2,4-dihydroxyphenyl substituent as anticancer agents.

Synthesis, characterization, and pharmacological evaluation of novel azolo- and azinothiazinones containing 2,4-dihydroxyphenyl substituent as anticancer agents.

Monatshefte fur chemie (2015-07-21)

Joanna Matysiak, Małgorzata Juszczak, Monika M Karpińska, Ewa Langner, Katarzyna Walczak, Marta Lemieszek, Alicja Skrzypek, Wojciech Rzeski, Andrzej Niewiadomy

ABSTRACT

We reported the synthesis and characterization of a series of azolo- and azino[1,3]thiazinones containing the 2,4-dihydroxyphenyl substituent. The compounds were prepared by a new one-step reaction of aryl-modified sulfinylbis[(2,4-dihydroxyphenyl)methanethione]s and the corresponding aminoazolo(azino)carboxamides. Their chemical structures were confirmed by IR, NMR:

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Methanol, SAJ special grade

Sigma-Aldrich

5-Amino-4-imidazolecarboxamide, 95%

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Methanol, HPLC Plus, ≥99.9%, poly-coated bottles

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Dimethyl sulfoxide-d₆, "100%", 99.96 atom % D, contains 0.03 % (v/v) TMS

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Dimethyl sulfoxide-d₆, "100%", 99.96 atom % D

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Dimethyl sulfoxide-d₆, "Special HOH", ≥99.9 atom % D

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Dimethyl sulfoxide-d₆, 99.9 atom % D, contains 0.03 % (v/v) TMS

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Dimethyl sulfoxide-d₆, 99.9 atom % D

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Methanol, suitable for HPLC

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Supelco

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