T4509

4-Thiouridine

≥98%

• Synonym(s): 4sU, RNA synthesis inhibitor, Thiouridine
• Empirical Formula (Hill Notation): C₉H₁₂N₂O₅S
• CAS Number: 13957-31-8
• Molecular Weight: 260.27
• EC Number: 237-735-3
• MDL number: MFCD00006538
• UNSPSC Code: 41106305
• PubChem Substance ID: 24900212
• NACRES: NA.51

Properties

• biological source: synthetic (organic)
• Assay: ≥98%
• form: powder
• solubility: water: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=S)NC2=O
• InChI: 1S/C9H12N2O5S/c12-3-4-6(13)7(14)8(16-4)11-2-1-5(17)10-9(11)15/h1-2,4,6-8,12-14H,3H2,(H,10,15,17)/t4-,6-,7-,8-/m1/s1
• InChI key: ZLOIGESWDJYCTF-XVFCMESISA-N

Description

General description

4-Thiouridine is a photoreactive uridine analog.

Application

4-Thiouridine has been used in labeling and isolation of nascent RNAs.

Biochem/physiol Actions

4-Thiouridine plays a role in assessing nascent RNA synthesis. It also enhances site-specific crosslinking. 4-Thiouridine also acts as a photoaffinity probe due to its stability even while lacking specific photoactivation. It can also be incorporated into RNAs.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves