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SAB1306616

Sigma-Aldrich

ANTI-PCM-1 (CENTER) antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

Synonym(s):

PCM1, Pericentriolar material 1 protein

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

228533 Da

species reactivity

human

technique(s)

flow cytometry: 1:10-1:50
immunofluorescence: 1:10-1:50
immunohistochemistry: 1:50-1:100
western blot: 1:1000

NCBI accession no.

NP_006188.3

UniProt accession no.

Q15154

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PCM1(5108)

General description

Pericentriolar material 1 (PCM1) is a centriolar satellite protein. The PCM1 gene is located on the human chromosome at 8p22.

Biochem/physiol Actions

Pericentriolar material 1 (PCM1) protein acts as a scaffold and facilitates the aggregation of target proteins to the centrosome during centrosome maturation. It forms a complex with Bardet-Biedl syndrome 4 protein (BBS4) and disrupted-in-schizophrenia 1 (DISC1) at the centrosome. PCM1 along with DISC1 and BBS4 plays a role in the centrosomal pathway that is associated with schizophrenia. It is involved in ciliogenesis by binding an E3 ligase enzyme to satellites. PCM1 regulates the primary cilia disassembly before mitotic entry by recruiting polo-like-kinase 1 (Plk1) to the pericentriolar matrix.

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Gang Wang et al.
Journal of cell science, 126(Pt 6), 1355-1365 (2013-01-25)
Primary cilia, which emanate from the cell surface, exhibit assembly and disassembly dynamics along the progression of the cell cycle. However, the mechanism that links ciliary dynamics and cell cycle regulation remains elusive. In the present study, we report that
Lei Wang et al.
eLife, 5 (2016-05-06)
To elucidate the role of centriolar satellites in ciliogenesis, we deleted the gene encoding the PCM1 protein, an integral component of satellites. PCM1 null human cells show marked defects in ciliogenesis, precipitated by the loss of specific proteins from satellites
Atsushi Kamiya et al.
Archives of general psychiatry, 65(9), 996-1006 (2008-09-03)
A role for the centrosome has been suggested in the pathology of major mental illnesses, especially schizophrenia (SZ). To show that pericentriolar material 1 protein (PCM1) forms a complex at the centrosome with disrupted-in-schizophrenia 1 (DISC1) and Bardet-Biedl syndrome 4

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