L7635
L-α-Lysophosphatidylinositol sodium salt from Glycine max (soybean)
≥96%
Synonym(s):
1-Acyl-sn-glycero-3-phospho-(1-D-myo-inositol)
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About This Item
Recommended Products
biological source
soybean
Assay
≥96%
form
powder
functional group
phospholipid
lipid type
phosphoglycerides
shipped in
ambient
storage temp.
−20°C
Application
L-α-Lysophosphatidylinositol sodium salt from Glycine max (soybean) has been used as an agonist of G protein-coupled receptor 55 (GPR55).
Biochem/physiol Actions
L-α-Lysophosphatidylinositols (LPI) functions as an endogenous ligand for putative cannabinoid receptor and G protein-coupled receptor 55 (GPR55). LPI plays a regulatory role in cell proliferation, migration and function. Increased circulatory levels of LPI has been observed in the obese patients. In addition, overexpression of LPI leads to the development of various types of cancers including ovarian and breast cancer. LPI can be used as a potential diagnostic and prognostic biomarker for ovarian cancer.
L-α-Lysophosphatidylinositols from Glycine max (soybean) are enriched with stearate and palmitate. Soybean Lysophosphatidylinositols may be compared with other lysophosphatidylinositol for biological activities which depend upon the identity of the acylated fatty acid.
Quality
Contains primarily palmitic and stearic acids.
Preparation Note
Prepared by the action of phospholipase A on L-α-phosphatidylinositol.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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A role for L-alpha-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells
Ford LA, et al.
British Journal of Pharmacology, 160(3), 762-771 (2010)
Lysophosphatidylinositol signalling: New wine from an old bottle.
Pi?eiro R, Falasca M.
Biochimica et Biophysica Acta, 182, 694-705 (2012)
The endocannabinoids anandamide and virodhamine modulate the activity of the candidate cannabinoid receptor GPR55
Sharir H, et al.
Journal of Neuroimmune Pharmacology, 7(4), 856-865 (2012)
The L-alpha-lysophosphatidylinositol/GPR55 system and its potential role in human obesity
Moreno-Navarrete J, et al.
Diabetes, 61(2), 281-291 (2012)
Ruth A Ross
Trends in pharmacological sciences, 32(5), 265-269 (2011-03-04)
Evidence points to a role of L-α-lysophosphatidylinositol (LPI) in cancer. First, clinical data identified LPI as a biomarker for poor prognosis in cancer patients. Second, in vitro studies demonstrated significantly elevated levels of LPI in highly proliferative cancer cells. Third
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