311R-1

PAX-2 (EP235) Rabbit Monoclonal Primary Antibody

clone EP235, unconjugated, Cell Marque^™

• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100; 500
• conjugate: unconjugated
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: EP235, monoclonal
• description: (For In Vitro Diagnostic Use in Select Regions (See Chart))
• form: buffered aqueous solution
• species reactivity: human
• packaging: bottle of 1.0 mL predilute (311R-17); bottle of 7.0 mL predilute (311R-18); vial of 0.1 mL concentrate (311R-14); vial of 0.5 mL concentrate (311R-15); vial of 1.0 mL concentrate (311R-16)
• manufacturer/tradename: Cell Marque^™
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50
• isotype: IgG
• shipped in: wet ice
• storage temp.: 2-8°C
• Gene Information: human ... PAX2(5076)

Description

General description

PAX-2 is a homeogene strongly expressed during kidney development. PAX-2 gene is expressed in the metanephric mesenchyma after ureter bud induction and is a key factor for the mesenchyma-epithelium conversion. Animals transgenic for PAX-2 have severe renal abnormalities and cysts but no solid tumoral features. The oncogenic potential of the PAX gene family has been reported <em>in vitro</em> with transformation of cell cultures and <em>in vivo</em> with cell injections in nude mice. Gnarra et al. showed PAX-2 expression in renal carcinoma cell lines and underlined its potential role in cell proliferation in these lines.¹ Mazal et al. demonstrated PAX-2 nuclear expression in 88% of clear cell renal cell carcinomas as well as 18% of papillary renal cell carcinoma, and 13% of chromophobe renal cell carcinomas.² More recently, Chivukula et al. demonstrated utility in distinguishing ovarian serous papillary carcinoma (anti-PAX-2 positive) from breast carcinoma (anti-PAX-2 negative).³

Quality

IVD

IVD

IVD

RUO

Linkage

PAX-2 Positive Control Slides, Product No. 311S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany