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S7007

Supelco

Sulfadimethoxine

98.0-102.0%

Synonym(s):

4-Amino-N-(2,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C12H14N4O4S
CAS Number:
122-11-2
Molecular Weight:
310.33
Beilstein:
306856
EC Number:
204-523-7
MDL number:
MFCD00057345
UNSPSC Code:
41116107
PubChem Substance ID:
329824574
NACRES:
NA.24

Quality Level

200

Assay

98.0-102.0%

form

powder

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

application(s)

forensics and toxicology
pharmaceutical (small molecule)

Mode of action

DNA synthesis | interferes
enzyme | inhibits

storage temp.

2-8°C

SMILES string

COc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(OC)n1

InChI

1S/C12H14N4O4S/c1-19-11-7-10(14-12(15-11)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)

InChI key

ZZORFUFYDOWNEF-UHFFFAOYSA-N

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General description

Chemical structure: sulfonamide

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase.
Mode of Action: Inhibits folic acid synthesis in prokaryotes.
Anti-microbial Spectrum: Gram positive, Gram negative, Chlamydia
Mode of Resistance: Alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000395332
0000395332
0000327784
0000242670
0000242669

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Annie von Eyken et al.
Journal of the American Society for Mass Spectrometry, 30(5), 765-777 (2019-03-17)
Non-targeted screening (e.g., suspected-target) is emerging as an attractive tool to investigate the occurrence of contaminants in food. The sample preparation and instrument analysis steps are known to influence the identification of analytes with non-targeted workflows, especially for complex matrices.
Alexandra Dheilly et al.
Antimicrobial agents and chemotherapy, 56(1), 189-196 (2011-10-12)
An experiment was conducted in animal facilities to compare the impacts of four avian colibacillosis treatments-oxytetracycline (OTC), trimethoprim-sulfadimethoxine (SXT), amoxicillin (AMX), or enrofloxacin (ENR)-on the susceptibility of Escherichia coli in broiler intestinal tracts. Birds were first orally inoculated with rifampin-resistant
Hiroichi Ozaki et al.
Veterinary microbiology, 150(1-2), 132-139 (2011-01-15)
To investigate the effects of rearing practices of commercial broiler chickens on the incidence of antimicrobial resistance in commensal Escherichia coli isolates, fecal E. coli isolates obtained in 4 farms were screened for anitimicrobial resistance. Ten E. coli isolates were
Ailiang Chen et al.
Biosensors & bioelectronics, 42, 419-425 (2012-12-12)
Quickly and sensitively detection of antibiotic residues in animal products often requires time-consuming techniques and expensive instrumentation. To address these limitations, a high sensitive aptasensor for sulfadimethoxine (SDM) using unmodified gold nanoparticles (AuNPs) was developed in the present study. The
Lou Ann Tom et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 909, 61-64 (2012-11-17)
Four non-covalently prepared molecularly imprinted polymers (MIPs) for sulfadimethoxine (SDM) were prepared using different ratios of SDM template, methacrylic acid monomer, and ethylene glycol dimethacrylate cross-linker. The imprinting factor (IF) was calculated by comparing the retention of SDM on the
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