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Key Documents

A9199

Sigma-Aldrich

2-Amino-2-methyl-1-propanol

BioXtra, ≥95%

Synonym(s):

β-Aminoisobutyl alcohol, AMP

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About This Item

Linear Formula:
(CH3)2C(NH2)CH2OH
CAS Number:
Molecular Weight:
89.14
Beilstein:
505979
EC Number:
MDL number:
UNSPSC Code:
12161700
PubChem Substance ID:
NACRES:
NA.25

vapor density

3 (vs air)

Quality Level

vapor pressure

<1 mmHg ( 25 °C)

product line

BioXtra

Assay

≥95%

form

liquid

impurities

≤0.005% Phosphorus (P)
≤0.1% Insoluble matter

ign. residue

≤0.1%

refractive index

n20/D 1.4455 (lit.)

pH

11.0-12 (25 °C, 8.9 g/L)

useful pH range

9.0-10.5

pKa (25 °C)

9.7

bp

165 °C (lit.)

mp

24-28 °C (lit.)

solubility

H2O: 0.5 M at 20 °C, clear, colorless

density

0.934 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.005%
Pb: ≤0.001%
Zn: ≤0.0005%

SMILES string

CC(C)(N)CO

InChI

1S/C4H11NO/c1-4(2,5)3-6/h6H,3,5H2,1-2H3

InChI key

CBTVGIZVANVGBH-UHFFFAOYSA-N

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Application

2-Amino-2-methyl-1-propanol has been used as an component in enzyme assay for screening the alkaline phosphatase activity in sarcoma osteogenic (SaOS-2) cells..

Biochem/physiol Actions

2-Amino-2-methyl-1-propanol is a substituted aliphatic alcohol and is used majorly as a pH balancer in cosmetic formulations. It has phototoxic effect as it can interact and penetrate above the sebum layer. However, it is not carcinogenic.

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Aquatic Chronic 3 - Eye Dam. 1 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

179.8 °F - closed cup

Flash Point(C)

82.1 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Phototoxic assessment of a sunscreen formulation and its excipients: An in vivo and in vitro study
Hossy BH, et al.
Journal of Photochemistry and Photobiology. B, Biology, 173(6), 545-550 (2017)
Final amended report on safety assessment on aminomethyl propanol and aminomethyl propanediol
Burnett CL, et al.
International Journal of Toxicology, 28(6), 141S-161S (2009)
The morphogenetically active polymer, inorganic polyphosphate complexed with GdCl3, as an inducer of hydroxyapatite formation in vitro
Wang X, et al.
Biochemical Pharmacology, 102(6), 97-106 (2016)
M Lamberto et al.
Analytical biochemistry, 230(2), 224-228 (1995-09-20)
The effect of derivatization with 2-amino-2-methyl-propanol on trans-3-hexadecenoic acid was investigated as part of the identification of the trans-3-hexadecenoic acid in two Nova Scotian seaweeds. After the extraction of the total fatty acids and their methylation, the monoenoic trans fraction
Shia-Chung Chen et al.
Journal of hazardous materials, 179(1-3), 692-700 (2010-04-15)
In this study, the recovery of carbon dioxide using an absorbent composed of 2-amino-2-methyl-l-propanol (AMP)+monoethanolamine (MEA)+piperazine (PZ) in polytetrafluoroethylene (PTFE) membrane contactors was investigated. Experiments were conducted using various gas flow rates, liquid flow rates, absorbent blends, and pore size

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