- Paucity of Plasmodium vivax mature schizonts in peripheral blood is associated with their increased cytoadhesive potential.
Paucity of Plasmodium vivax mature schizonts in peripheral blood is associated with their increased cytoadhesive potential.
The Journal of infectious diseases (2014-01-15)
Stefanie C P Lopes, Letusa Albrecht, Bruna O Carvalho, André M Siqueira, Richard Thomson-Luque, Paulo A Nogueira, Carmen Fernandez-Becerra, Hernando A Del Portillo, Bruce M Russell, Laurent Rénia, Marcus V G Lacerda, Fabio T M Costa
PMID24415786
ABSTRACT
There is now a growing body of evidence that challenges the current view that Plasmodium vivax-infected erythrocyte (Pv-iE) are unable to sequester. Here we used ex vivo adhesion assays with Pv-iE before and after maturation to demonstrate a higher binding potential of schizonts compared to other asexual stages. These experimental results are correlated with our observations in a panel of 50 vivax malaria patients where schizonts were completely absent in 27 isolates, and few schizonts were observed in the remaining patients. These observations prompt a paradigm shift in P. vivax biology and open avenues to investigate the role of Pv-iE sequestration.