- 2-Lithiated-2-phenyloxetane: a new attractive synthon for the preparation of oxetane derivatives.
2-Lithiated-2-phenyloxetane: a new attractive synthon for the preparation of oxetane derivatives.
Chemical communications (Cambridge, England) (2011-08-05)
Donato Ivan Coppi, Antonio Salomone, Filippo Maria Perna, Vito Capriati
PMID21814695
ABSTRACT
A valuable and direct method to access 2-substituted-2-phenyloxetanes by electrophilic quenching of the corresponding 2-lithiated derivative has, for the first time, been described. 2-Lithiated-2-phenyloxetane was found to be configurationally unstable. Evidence is presented to show that electron-transfer processes are also operative in the coupling reactions with electrophiles.
MATERIALS