- Solid state grinding as a tool to aid enantiomeric resolution by cocrystallisation.
Solid state grinding as a tool to aid enantiomeric resolution by cocrystallisation.
Chemical communications (Cambridge, England) (2012-10-18)
Mark D Eddleston, Mihails Arhangelskis, Tomislav Friščić, William Jones
PMID23073186
ABSTRACT
The formation of diastereomeric cocrystals of malic acid and tartaric acid was investigated by liquid-assisted grinding in the solid state. We demonstrate that racemic malic acid can be converted into two distinct diastereomeric cocrystal phases by grinding with a single enantiomer of tartaric acid.
MATERIALS
Product Number
Brand
Product Description
Supelco
L-(+)-Tartaric acid, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
Sigma-Aldrich
L-(+)-Tartaric acid, puriss., meets analytical specification of Ph. Eur., NF, 99.7-100.5% (calc. to the dried substance), powder
Sigma-Aldrich
L-(+)-Tartaric acid, puriss. p.a., reag. ISO, 99.5-101.0% (calc. to the dried substance)