- [Cytokine synthesis in the healthy volunteer's blood mononuclear cells under the influence of an indolyl-thio-alkanecarboxylic acid derivative with selective immunosuppressant properties].
[Cytokine synthesis in the healthy volunteer's blood mononuclear cells under the influence of an indolyl-thio-alkanecarboxylic acid derivative with selective immunosuppressant properties].
Eksperimental'naia i klinicheskaia farmakologiia (2010-04-23)
I A Gol'dina, I V Safronova, K V Gaĭdul', V A Kozlov
PMID20408426
ABSTRACT
The influence of BM-7-02 compound on the production of cytokines in the culture of healthy volunteers' blood cells. This compound suppresses the production of main cytokine (gamma-IFN, IL-2 and IL-4) synthesized by CD4+ Th1 and Th2 cells, stimulates the production of TNF-alpha and IL-6, and does not change the production of IL-1 beta.