- Bioprinting of Cartilage with Bioink Based on High-Concentration Collagen and Chondrocytes.
Bioprinting of Cartilage with Bioink Based on High-Concentration Collagen and Chondrocytes.
International journal of molecular sciences (2021-11-14)
Evgeny E Beketov, Elena V Isaeva, Nina D Yakovleva, Grigory A Demyashkin, Nadezhda V Arguchinskaya, Anastas A Kisel, Tatiana S Lagoda, Egor P Malakhov, Valentin I Kharlov, Egor O Osidak, Sergey P Domogatsky, Sergey A Ivanov, Petr V Shegay, Andrey D Kaprin
PMID34768781
ABSTRACT
The study was aimed at the applicability of a bioink based on 4% collagen and chondrocytes for de novo cartilage formation. Extrusion-based bioprinting was used for the biofabrication. The printing parameters were tuned to obtain stable material flow. In vivo data proved the ability of the tested bioink to form a cartilage within five to six weeks after the subcutaneous scaffold implantation. Certain areas of cartilage formation were detected as early as in one week. The resulting cartilage tissue had a distinctive structure with groups of isogenic cells as well as a high content of glycosaminoglycans and type II collagen.
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