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SML3391

Sigma-Aldrich

Glatiramer acetate

≥95% (HPLC)

Synonym(s):

Cop 1 (polyamide), Cop-1, Copaxone, Copolymer 1, GA, Polymer with L-alanine, L-lysine, L-tyrosine, and L-glutamic acid acetate

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About This Item

Linear Formula:
(C9H11NO3)a·(C6H14N2O2)b ·(C5H9NO4)c ·(C3H7NO2)d ·x(CH3CO2H)
UNSPSC Code:
12352200
NACRES:
NA.21

Quality Level

100

Assay

≥95% (HPLC)

form

(Powder or Lyophilized powder or film)

storage condition

desiccated

color

white to beige

storage temp.

-10 to -25°C

SMILES string

OC([C@@H](N)C)=O.OC(CC[C@H](N)C(O)=O)=O.NCCCC[C@H](N)C(O)=O.OC([C@@H](N)CC1=CC=C(C=C1)O)=O

Biochem/physiol Actions

Glatiramer acetate, a myelin basic protein mimetic, is an immunomodulator used for treatment of Multiple Sclerosis. Glatiramer acetate is a mixture of synthetic peptides randomly composed of glutamic acid, lysine, alanine, and tyrosine. It reduces relapse rate and disease progression in Multiple Sclerosis. Its mechanism of action is not fully understood. Glatiramer acetate generates anti-inflammatory Th2 cells, which produce neurotrophic factors.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Glatiramer acetate attenuates depressive/anxiety-like behaviors and cognitive deficits induced by post-weaning social isolation in male mice
Sanusi Andah Salihu , Homanaz Ghafari ,Narges K Gortany
Psychopharmacology, 238, 2121-2132 (2021)
Effects of methylprednisolone and glatiramer acetate on nitric oxide formation of cytokine-stimulated cells from the rat oligodendroglial cell line OLN-93
Christian Holzknecht
Neuroimmunomodulation, 17, 23-30 (2010)
Synthetic Cationic Autoantigen Mimics Glatiramer Acetate Persistence at the Site of Injection and Is Efficacious Against Experimental Autoimmune Encephalomyelitis
Song JY, Griffin JD, Larson NR, Christopher MA, Middaugh CR, Berkland CJ
Frontiers in Immunology, 11, 603029-603029 (2021)

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