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840022C

Avanti

Brain PE

Avanti Research™ - A Croda Brand 840022C

Synonym(s):

L-α-phosphatidylethanolamine (Brain, Porcine)

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About This Item

CAS Number:
383907-18-4
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (840022C-25mg)
pkg of 2 × 4 mL (840022C-200mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 840022C

concentration

10 mg/mL (840022C-25mg)
25 mg/mL (840022C-200mg)

lipid type

phosphoglycerides

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCC[NH3+])=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O

InChI

1S/C41H80NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h18,20,39H,3-17,19,21-38,42H2,1-2H3,(H,45,46)/b20-18-/t39-/m1/s1

InChI key

JQKOHRZNEOQNJE-DJEJVYNPSA-N

General description

Contains ~50% plasmalogen ether lipid

Application

Brain PE has been used as a cofactor to support the replication of highly infectious prion protein (PrPSc). It has also been used for the preparation of liposomes.

Packaging

5 mL Clear Glass Sealed Ampule (840022C-200mg)
5 mL Clear Glass Sealed Ampule (840022C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

also commonly purchased with this product

Product No.
Description
Pricing

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system, Liver,Kidney

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Preserving prion strain identity upon replication of prions in vitro using recombinant prion protein
Makarava N, et al.
Acta Neuropathologica Communications, 6(1), 92-92 (2018)
Contrasting effects of two lipid cofactors of prion replication on the conformation of the prion protein
Srivastava S and Baskakov IV
Testing, 10(6), e0130283-e0130283 (2015)
Arupratan Das et al.
Nature cell biology, 14(3), 304-310 (2012-02-22)
Lipid asymmetry at the plasma membrane is essential for such processes as cell polarity, cytokinesis and phagocytosis. Here we find that a lipid flippase complex, composed of Lem3, Dnf1 or Dnf2, has a role in the dynamic recycling of the
Saurabh Srivastava et al.
PloS one, 10(6), e0130283-e0130283 (2015-06-20)
Recent studies introduced two experimental protocols for converting full-length recombinant prion protein (rPrP) purified from E.coli into the infectious prion state (PrPSc) with high infectivity titers. Both protocols employed protein misfolding cyclic amplification (PMCA) for generating PrPSc de novo, but
Gillian L Dornan et al.
Structure (London, England : 1993), 28(2), 145-156 (2019-12-14)
The class I phosphoinositide 3-kinases (PI3Ks) are key signaling enzymes composed of a heterodimer of a p110 catalytic subunit and a p85 regulatory subunit, with PI3K mutations being causative of multiple human diseases including cancer, primary immunodeficiencies, and developmental disorders.
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