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Multiple roles of integrin-α3 at the neuromuscular junction.

Journal of cell science (2017-04-08)
Jacob A Ross, Richard G Webster, Tanguy Lechertier, Louise E Reynolds, Mark Turmaine, Maximilien Bencze, Yalda Jamshidi, Hakan Cetin, Francesco Muntoni, David Beeson, Kairbaan Hodilvala-Dilke, Francesco J Conti
ABSTRACT

The neuromuscular junction (NMJ) is the synapse between motoneurons and skeletal muscle, and is responsible for eliciting muscle contraction. Neurotransmission at synapses depends on the release of synaptic vesicles at sites called active zones (AZs). Various proteins of the extracellular matrix are crucial for NMJ development; however, little is known about the identity and functions of the receptors that mediate their effects. Using genetically modified mice, we find that integrin-α3 (encoded by

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Monoclonal Anti-Neurofilament 160 antibody produced in mouse, clone NN18, ascites fluid
Sigma-Aldrich
Anti-p62/SQSTM1 antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution