- RASSF6 downregulation promotes the epithelial-mesenchymal transition and predicts poor prognosis in colorectal cancer.
RASSF6 downregulation promotes the epithelial-mesenchymal transition and predicts poor prognosis in colorectal cancer.
Oncotarget (2017-09-15)
Rui Zhou, Lin Qiu, Xiaolong Liu, Lijuan Ling, Ninglei Li, Kun Zhou, Jingbo Sun, Jian Yan, Canliang Tan, Xiaoping Huang, Luzhe Han, Liangchun Yin, Gang Xiao, Lixin Liu
PMID28903410
ABSTRACT
Distant metastasis is the primary barrier for the successful treatment of patients with colorectal cancer, and thus, searching for new therapeutic targets by further exploring the molecular mechanisms of colorectal cancer metastasis is important. In this study, we investigated the biological and clinical significance of RASSF6 in colorectal cancer as well as the underlying molecular mechanisms. We found that low RASSF6 expression corresponds to a poor prognosis in colorectal cancer patients, and low RASSF6 expression is distinctly associated with tumour progression. Our
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