- A MALDI-chip integrated system with a monitoring window.
A MALDI-chip integrated system with a monitoring window.
Lab on a chip (2005-03-26)
Monica Brivio, Niels R Tas, Martijn H Goedbloed, Han J G E Gardeniers, Willem Verboom, Albert van den Berg, David N Reinhoudt
PMID15791334
ABSTRACT
The integration of a monitoring port along the microfluidic path of a MALDI-chip integrated device is described. Optimization of the microreactor design allows longer reaction and measuring times. The Schiff base reaction between 4-tert-butylaniline (1) and 4-tert-butylbenzaldehyde (2) in ethanol was carried out on-chip in the MALDI ionization chamber and the formed imine 3 was detected in real time, demonstrating the feasibility of the "monitoring window" approach. This preliminary result opens the way to on-chip kinetic studies by MALDI-MS, by opening multiple monitoring windows along the microchannel.