- N,N'-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptors.
N,N'-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptors.
Bioorganic & medicinal chemistry letters (2006-08-29)
Hong Nie, Katherine L Widdowson, Michael R Palovich, Wei Fu, John D Elliott, Deborah L Bryan, Miriam Burman, Dulcie B Schmidt, James J Foley, Henry M Sarau, Jakob Busch-Petersen
PMID16934456
ABSTRACT
A series of N-(2-hydroxy-3-sulfonamidobenzene)-N'-arylcyanoguanidines was prepared. In general, these compounds proved to be potent antagonists of CXCR2 while the selectivity versus CXCR1 ranged from non-selective to >200-fold.
MATERIALS