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796-0275

GC Analysis of Tricyclic Antidepressants in Urine on a 100% Methyl Column after SPME using 100 μm PDMS Fiber

suitable for GC, application for SPME

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technique(s)

gas chromatography (GC): suitable
solid phase microextraction (SPME): suitable

test parameters

sample/matrix: 1 mL urine (1 μg each analyte + 50 μL 5 M NaOH) in 7.5 mL vial
SPME fiber: polydimethylsiloxane, 100 μm (57300-U)
extraction: headspace, 15 min, 100 °C (sample incubated 30 min)
desorption process: 3 min, 280 °C
column: 100% methyl polysiloxane, 30 m × 0.32 mm I.D., 0.25 μm (Supelco equivalent, Equity-1, 28055-U)
oven: 100 °C to 300 °C at 20 °C/min
inj. temp.: splitless (splitter opened after 1 min), 280 °C
detector: FID, 280 °C
carrier gas: helium, 30 cm/sec

suitability

application for SPME

application(s)

clinical
forensics and toxicology


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