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Key Documents

SAB1305503

Sigma-Aldrich

MONOCLONAL ANTI-CD25 antibody produced in mouse

clone 7G7B6, crude ascites, buffered aqueous solution

Synonym(s):

CD_antigen=CD25, IL2RA, Interleukin-2 receptor subunit alpha, TAC antigen, p55

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

antibody form

crude ascites

antibody product type

primary antibodies

clone

7G7B6, monoclonal

form

buffered aqueous solution

mol wt

30819 Da

species reactivity

human

technique(s)

western blot: 1:100-~1:800

isotype

IgG2a

NCBI accession no.

NP_000408.1

UniProt accession no.

P01589

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IL2RA(3559)

General description

The CD25 gene, also referred to as IL2RA (interleukin 2 receptor subunit α), is mapped to human chromosome 10p15. The gene spans a length of 48 kb with eight exons.

Biochem/physiol Actions

The interleukin 2 receptor subunit α (IL2RA) gene encodes the α-chain of the IL-2 receptor complex. This receptor complex, made up of α, β, and a common γ chain, binds to its ligand, IL-2, which is a crucial growth factor for T- and B-cells. This ligand-receptor complex plays an important role in the regulation of immune responses. Variation in the chromosomal region containing this gene is associated with type 1 diabetes. This region is also linked to autoimmune thyroid disease indicating its role in autoimmunity. IL2RA has been found to confer a risk for multiple sclerosis.

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.
Maier L M, et al.
PLoS Genetics, 5(1), e1000322-e1000322 (2009)
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.
Lowe C E, et al.
Nature Genetics, 39(9), 1074-1074 (2007)
Toward further mapping of the association between the IL2RA locus and type 1 diabetes.
Qu H Q, et al.
Diabetes, 56(4), 1174-1176 (2007)
IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations.
Weber F, et al.
Genes and Immunity, 9(3), 259-259 (2008)

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