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A3846

Sigma-Aldrich

AL-8810

≥98% (HPLC), solid

Synonym(s):

(5Z, 13E)-(9S,11S,15R)-9,15,Dihydroxy-11-fluoro-15-(2-indanyl)-16,17,18,19,20,pentanor-5,13-prostadienoic acid, [1R-[1α(Z),2β(1E,3S*),3β,5α]]-7-[3-Fluoro-5-hydroxy-2-[3-hydroxy-4-[2-(2,3-dihydro-1H-indenyl)]-1-butenyl]cyclolpentyl]-5-heptenoic acid

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About This Item

Empirical Formula (Hill Notation):
C24H31FO4
CAS Number:
246246-19-5
Molecular Weight:
402.50
MDL number:
MFCD04039992
UNSPSC Code:
51111800
PubChem Substance ID:
24278225
NACRES:
NA.77

Assay

≥98% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: soluble 10 mg/mL
ethanol: soluble

storage temp.

2-8°C

SMILES string

O[C@H]1C[C@H](F)[C@H](\C=C\[C@H](O)C2Cc3ccccc3C2)[C@H]1C\C=C/CCCC(O)=O

InChI

1S/C24H31FO4/c25-21-15-23(27)20(9-3-1-2-4-10-24(28)29)19(21)11-12-22(26)18-13-16-7-5-6-8-17(16)14-18/h1,3,5-8,11-12,18-23,26-27H,2,4,9-10,13-15H2,(H,28,29)/b3-1-,12-11+/t19-,20-,21+,22+,23+/m1/s1

InChI key

WTYSXBKKVNOOIX-JTGCGUAKSA-N

Gene Information

human ... PTGFR(5737)

Biochem/physiol Actions

AL-8810 is a novel prostaglandin F2α analog; selective FP prostanoid receptor antagonist.

Legal Information

Sold under license from Alcon.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Dedmer Schaafsma et al.
Respiratory research, 6, 85-85 (2005-07-29)
In addition to their proliferative and differentiating effects, several growth factors are capable of inducing a sustained airway smooth muscle (ASM) contraction. These contractile effects were previously found to be dependent on Rho-kinase and have also been associated with the
Evanthia Nikolopoulou et al.
Journal of lipid research, 55(12), 2479-2490 (2014-10-18)
Arachidonic acid (AA) is a major PUFA that has been implicated in the regulation of adipogenesis. We examined the effect of a short exposure to AA at different stages of 3T3-L1 adipocyte differentiation. AA caused the upregulation of fatty acid

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