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331589

Sigma-Aldrich

Diphenylacetyl chloride

90%, technical grade

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About This Item

Linear Formula:
(C6H5)2CHCOCl
CAS Number:
1871-76-7
Molecular Weight:
230.69
EC Number:
217-493-5
MDL number:
MFCD00013655
UNSPSC Code:
12352100
PubChem Substance ID:
24859978
NACRES:
NA.22
Pricing and availability is not currently available.

grade

technical grade

Assay

90%

form

solid

bp

175-176 °C/17 mmHg (lit.)

mp

49-53 °C (lit.)

SMILES string

ClC(=O)C(c1ccccc1)c2ccccc2

InChI

1S/C14H11ClO/c15-14(16)13(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10,13H

InChI key

MSYLETHDEIJMAF-UHFFFAOYSA-N

Application

Diphenylacetyl chloride was used as a reagent in regioselective acylation of cyclomalto-oligosaccharides.[1] It was also used in the preparation of N-substituted amides having local anesthetic properties.[2]

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 2

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKBQ4018V
MKBL7220V
36697LJ
04917JH
13614TC

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F El-Zahraa et al.
Die Pharmazie, 34(1), 12-13 (1979-01-01)
Diphenylacetyl chloride and pivaloyl chloride have been condensed with a wide variety of amines. Some of the resulting amides showed local anesthetic properties higher than those of procaine hydrochloride.
F Santoyo-González et al.
Carbohydrate research, 262(2), 271-282 (1994-09-15)
Regioselective acylation of cyclomalto-oligosaccharides was achieved using pivaloyl and diphenylacetyl chlorides. The reaction of cyclomaltohexaose (1) with pivaloyl chloride gave the hexakis(2,6-di-O-pivaloyl) derivative 19 in 66% yield. Similar reaction with cyclomalto-heptaose (2) led to the octakis(2I,6I,6II,6III,6IV,6V,6VI ,6VII-O-pivaloyl) 26 and the
Jinyeon Hwang et al.
Experimental neurology, 335, 113511-113511 (2020-10-26)
Cyclin-dependent kinase 5 (Cdk5) is involved in neural organization and synaptic functions in developing and adult brains, yet its role in axonal regeneration is not known well. Here, we characterize Cdk5 function for axonal regeneration after peripheral nerve injury. Levels

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