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Merck

SIRT6

sirtuin 6

Synonyms:
SIR2L6
Species:
UniProtKB ID:
Gene ID:
  • Human(51548) Summary: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]
  • Mouse(50721) sirtuin 6
  • Rat(299638) sirtuin 6
  • naked mole-rat(101706114) sirtuin 6
  • sheep(101113327) sirtuin 6
  • chicken(428332) sirtuin 6
  • domestic cat(101100540) sirtuin 6
  • cow(535416) sirtuin 6
  • Zebrafish(415161) sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
  • dog(485045) sirtuin 6
  • fruit fly(41254) CG6284 gene product from transcript CG6284-RB
  • domestic guinea pig(100734667) sirtuin 6

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-SIRT6 Antibody, clone 1D0L6, Rabbit Monoclonal, ,
Species Reactivity
human
Application
western blot
Anti-Sirt6 (C-terminal) antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
Monoclonal Anti-SIRT6 antibody produced in mouse, clone 1D8, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
Anti-SIRT6 antibody produced in chicken, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
Anti-SIRT6 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry

Proteins

Product Number
Description
Species
Sirtuin 6 human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Species
human
SIRT6, active, His tagged human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Sirt6,
Species
mouse
MISSION® esiRNA, targeting human SIRT6,
Species
human