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Merck

EP300

E1A binding protein p300

Synonyms:
KAT3B, RSTS2, p300
Species:
Human EP300 (2033), Mouse Ep300 (328572), Rat Ep300 (170915), dog EP300 (100684945), domestic guinea pig Ep300 (100734820), chicken EP300 (418000), domestic cat EP300 (101088344), naked mole-rat Ep300 (101711512), Horse EP300 (100055626), sheep EP300 (101110136)
UniProtKB ID:
Q09472, B1AKC2
Gene ID:
  • Human(2033) Summary: This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]
  • Mouse(328572) E1A binding protein p300
  • Rat(170915) E1A binding protein p300
  • dog(100684945) E1A binding protein p300
  • domestic guinea pig(100734820) E1A binding protein p300
  • chicken(418000) E1A binding protein p300
  • domestic cat(101088344) E1A binding protein p300
  • naked mole-rat(101711512) E1A binding protein p300
  • Horse(100055626) E1A binding protein p300
  • sheep(101110136) E1A binding protein p300

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB1400094
Monoclonal Anti-EP300 antibody produced in mouse, clone 1B1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
SAB1403776
Monoclonal Anti-EP300 antibody produced in mouse, clone 1D2, ascites fluid,
Species Reactivity
human
Application
ELISA
western blot
05-257
Anti-p300 CT Antibody, clone RW128, clone RW128, Upstate®, from mouse,
Species Reactivity
human, mouse, rat
Application
ChIP
immunoprecipitation (IP)
western blot
HPA003128
Anti-EP300 antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
SAB4503952
Anti-phospho-p300 (pSer89) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

Proteins

Product Number
Description
Species
SRP2086
p300 (C1135-2414) human, recombinant, expressed in insect cells, ≥70% (SDS-PAGE),
Species
human
SRP5110
P300 (1283-1673), GST tagged human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
14-418
p300, HAT Domain, Recombinant GST-fusion protein corresponding to amino acids 1066-1707 of human p300.,
Species
human

esiRNA

Product Number
Description
Species
EHU155151
MISSION® esiRNA, targeting human EP300,
Species
human
EMU078861
MISSION® esiRNA, targeting mouse Ep300,
Species
mouse