CCND1
cyclin D1
Synonyms:
BCL1, D11S287E, PRAD1, U21B31
Species:
Human CCND1 (595), Mouse Ccnd1 (12443), Rat Ccnd1 (58919), sheep CCND1 (100144763), Domestic Rabbit CCND1 (100009036), Zebrafish ccnd1 (30222), dog CCND1 (449028), cow CCND1 (524530), domestic guinea pig Ccnd1 (100729808), chicken CCND1 (396341) ...More
UniProtKB ID:
Gene ID:
- Human(595) Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]
- Mouse(12443) cyclin D1
- Rat(58919) cyclin D1
- sheep(100144763) cyclin D1
- Domestic Rabbit(100009036) cyclin D1
- Zebrafish(30222) cyclin D1
- dog(449028) cyclin D1
- cow(524530) cyclin D1
- domestic guinea pig(100729808) cyclin D1
- chicken(396341) cyclin D1
- domestic cat(100037407) cyclin D1
- naked mole-rat(101712621) cyclin D1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-CCND1 (ab1) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
guinea pig, human, mouse, rat
Application
western blot
Anti-CCND1 (ab2) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
western blot
Anti-CCND1 (ab3) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, human, pig
Application
immunohistochemistry
western blot
western blot
Anti-Phospho-CCND1-T286 antibody produced in rabbit, ,
Species Reactivity
human, rat
Application
western blot
Anti-Phospho-CCND1-T286 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
Proteins
Product Number
Description
Species
CDK6/CyclinD1, active, His/GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
CDK4/Cyclin D1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
CDK4/Cyclin D1 active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE),
Species
human