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Key Documents

SAB4504276

Sigma-Aldrich

Anti-phospho-CDK5 (pTyr15) antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 33 kDa

species reactivity

mouse, human, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
western blot: 1:500-1:1000

NCBI accession no.

Q00535

UniProt accession no.

Q00535

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pTyr15)

Gene Information

human ... CDK5(1020)

General description

Cyclin-dependent kinase 5 (CDK5) belongs to the CDKs family. Active CDK5 is present in pancreatic β cells, corneal epithelial cells and monocytes. This gene is mapped to human chromosome 7q36.

Immunogen

The antiserum was produced against synthesized peptide derived from human CDK5 around the phosphorylation site of Tyr15.

Immunogen Range: 1-50

Biochem/physiol Actions

Cyclin-dependent kinase 5 (CDK5) controls migration and neuronal plasticity. This protein participates in neuron migration, neurite outgrowth and support and synaptogenesis. It also helps in the development of lymphatic vessels. Suppressing Cdk5 promotes cell death of tumor-initiating cells.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Biological functions of CDK5 and potential CDK5 targeted clinical treatments
Shupp A, et al.
Oncotarget, 8(10), 17373-17382 (2017)
Inhibition of Cdk5 induces cell death of tumor-initiating cells
Mandl MM, et al.
British Journal of Cancer, 116(7), 912-922 (2017)
Evaluation and clinical significance of cyclin-dependent kinase5 expression in cervical lesions: a clinical research study in Guangxi, China
Pan DH, et al.
European Journal of Medical Research, 21(1), 28-28 (2016)
Cyclin-dependent kinase 5 controls vasculogenic mimicry formation in non-small cell lung cancer via the FAK-AKT signaling pathway
Zhou X, et al.
Biochemical and Biophysical Research Communications, 492(3), 447-452 (2017)
Chia-Yi Su et al.
Scientific reports, 9(1), 13703-13703 (2019-09-25)
Cyclin-dependent kinase 5 (Cdk5) is predominantly expressed in neuron and plays an important role in neuronal physiology. Increasing evidence also indicates that Cdk5 may contribute to malignant progression of some types of cancers; however, the underlying mechanism remains elusive. In
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