P3351
Protein L–Agarose from Peptostreptococcus magnus
recombinant, expressed in E. coli
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About This Item
UNSPSC Code:
41106500
NACRES:
NA.56
Recommended Products
recombinant
expressed in E. coli
matrix
6% beaded agarose supplied as 50% slurry
matrix activation
cyanogen bromide
matrix attachment
amino
capacity
3-10 mg/mL binding capacity
storage temp.
2-8°C
Application
Protein L-agarose is used in affinity chromatography, protein chromatography, antibody purification and characterization, immunoaffinity matrices, phosphorylation analysis, and protein A, G and L resins. Protein L-agarose has been used to provide evidence that antineuronal antibodies may contribute to neuronal dysfunction observed in a subset of patients with neurogenic chronic intestinal pseudoobstruction. Protein L agarose has also been used to evaluate a diabody to improve protection againse a potent scorpion neurotoxin.
Protein L from Peptostreptococcus magnus binds immunoglobulins (Ig) primarily through kappa light chain interactions without interfering with the antigen binding site. Recombinant Protein L contains four Ig-binding domains.
Preparation Note
Prepared with recombinant Peptostreptococcus magnus Protein L.
Storage Class Code
3 - Flammable liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Diabodies are recombinant, dimeric, antibody-based molecules composed of two non-covalently associated single-chain antibody fragments that bind to an antigen in a divalent manner. In an attempt to develop more effective therapeutic molecules against scorpion venoms, we designed a diabody derived
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