Iscove′s Modified Dulbecco′s Medium (IMDM) is a modification of the Dulbecco′s modified Eagle′s medium (DME) and contains additional amino acids, vitamins, selenium, sodium pyruvate, HEPES buffer, and potassium nitrate. This medium supports the growth of murine B lymphocytes, T lymphocytes, hemopoietic tissue from bone marrow, B cells stimulated with lipopolysaccharide, and other hybrid cells.
Application
Iscove′s Modified Dulbecco′s Medium has been used for the differentiation of pluripotent stem cells (PSCs).[1][2]
(1) Background: Human exposure to organophosphorus compounds employed as pesticides or as chemical warfare agents induces deleterious effects due to cholinesterase inhibition. One therapeutic approach is the reactivation of inhibited acetylcholinesterase by oximes. While currently available oximes are unable to
Behavioral and brain functions : BBF, 7, 47-47 (2011-11-22)
Recent advances in cell biology and gene regulation suggest mechanisms whereby associative learning could be performed by single cells. Therefore, we explored a model of classical conditioning in human macrophages in vitro. In macrophage cultures, bacterial lipopolysaccharide (LPS; unconditioned stimulus)
Proceedings of the National Academy of Sciences of the United States of America, 105(25), 8691-8696 (2008-06-20)
A model of chemical thymectomy by inducible Rag ablation was used to study peripheral T cell homeostasis. Induction of Rag ablation was efficient and complete, leading to cessation of thymic T cell production within 3-4 weeks. The decay of peripheral
Molecular and cellular biology, 29(7), 1774-1785 (2009-01-23)
Conditions causing an increase in misfolded or aberrant proteins can impair the activity of the ubiquitin/proteasome system (UPS). This observation is of particular interest, given the fact that proteotoxic stress is closely associated with a large variety of disorders. Although
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