222429

5-Methylisatin

95%

• Synonym(s): 5-Methylindole-2,3-dione, NSC 9398
• Empirical Formula (Hill Notation): C₉H₇NO₂
• CAS Number: 608-05-9
• Molecular Weight: 161.16
• EC Number: 210-152-1
• MDL number: MFCD00005721
• UNSPSC Code: 12352100
• PubChem Substance ID: 24853331
• NACRES: NA.22

Properties

• Assay: 95%
• form: solid
• mp: 180 °C (dec.) (lit.)
• solubility: methanol: soluble 25 mg/mL, clear to slightly hazy, orange to red
• SMILES string: Cc1ccc2NC(=O)C(=O)c2c1
• InChI: 1S/C9H7NO2/c1-5-2-3-7-6(4-5)8(11)9(12)10-7/h2-4H,1H3,(H,10,11,12)
• InChI key: VAJCSPZKMVQIAP-UHFFFAOYSA-N

Description

General description

5-Methylisatin is an inhibitor of atrial natriuretic peptide (ANP) receptor coupled with guanylyl cyclase (GC).

Application

5-Methylisatin was used as an internal standard during the determination of isatin (indole-2, 3-
dione) in body fluids by capillary column gas chromatography-mass spectrometry (GC—MS).

Reactant for preparation of:

• Antimycobacterial agents
• Promoters of central nervous system (CNS) depression in mice
• Inhibitors of TAK1 kinase
• Anti-human immunodeficiency virus (HIV) agent
• Potent herpes simplex virus (HSV) inhibitors
• Antimicrobial agents
• IKKβ inhibitors
• Potential drug to combat human immunodeficiency virus-tuberculosis (HIV-TB) coinfection
• Cyclooxygenase 1/2 (COX-1/2) and 5-lipoxygenase (5-LOX) inhibitors
• Antibacterial and anticancer agents

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves