Novel supports in chiral stationary phase development for liquid chromatography. Preparation, characterization and application of ordered mesoporous silica particles.

Novel supports in chiral stationary phase development for liquid chromatography. Preparation, characterization and application of ordered mesoporous silica particles.

Journal of chromatography. A (2014-07-13)

Isabel Sierra, Damián Pérez-Quintanilla, Sonia Morante, Judith Gañán

ABSTRACT

Recent advances in the development of new materials are having a major impact on analytical chemistry. For example, the unique properties of ordered mesoporous silicas (OMSs) have been shown to enhance the analytical performance of many existing techniques or allow new, exciting ones to be developed. Likewise, the introduction of organo-functional groups makes OMSs highly versatile and enables them to perform specialized tasks, such as the separation of chiral compounds. This review provides an overview with the most relevant achievements in the preparation of OMS particles functionalized with chiral selectors. In addition, some examples from the last fifteen years regarding the analytical applications of functionalized OMS for chiral separations by high-performance liquid chromatography, ultra-high pressure high-performance liquid chromatography and capillary electrochromatography have been reviewed.

MATERIALS

Product Number

Brand

Product Description

718483

Sigma-Aldrich

Silica, nanopowder, 99.8% trace metals basis

637238

Sigma-Aldrich

Silicon dioxide, nanopowder, 10-20 nm particle size (BET), 99.5% trace metals basis

643645

Sigma-Aldrich

Silica, mesostructured, MCM-41 type (hexagonal)

637246

Sigma-Aldrich

Silicon dioxide, nanopowder (spherical, porous), 5-20 nm particle size (TEM), 99.5% trace metals basis

748161

Sigma-Aldrich

Silica, nanoparticles, mesoporous, 200 nm particle size, pore size 4 nm

560979

Sigma-Aldrich

Silica, mesostructured, MSU-F (cellular foam)

420824

Sigma-Aldrich

LUDOX^® HS-30 colloidal silica, 30 wt. % suspension in H₂O

420794

Sigma-Aldrich

LUDOX^® SM colloidal silica, 30 wt. % suspension in H₂O

420786

Sigma-Aldrich

LUDOX^® TM-40 colloidal silica, 40 wt. % suspension in H₂O

420808

Sigma-Aldrich

LUDOX^® LS colloidal silica, 30 wt. % suspension in H₂O

421553

Sigma-Aldrich

Silica

913855

Sigma-Aldrich

Silica, mesoporous SBA-15, <150 μm particle size, pore size 12 nm, Hexagonal pore morphology

805890

Sigma-Aldrich

Silica, mesoporous, 0.5 μm particle size, pore size ~2 nm

420883

Sigma-Aldrich

LUDOX^® CL colloidal silica, 30 wt. % suspension in H₂O

806854

Sigma-Aldrich

Silica, mesoporous SBA-15, <150 μm particle size, pore size 8 nm, Hexagonal pore morphology

806811

Sigma-Aldrich

Silica, mesoporous, 1 μm particle size, pore size ~2 nm

806889

Sigma-Aldrich

Silica, mesoporous, 1 μm particle size, pore size ~4 nm

806803

Sigma-Aldrich

Silica, mesoporous SBA-15, <150 μm particle size, pore size 4 nm, Hexagonal pore morphology

806900

Sigma-Aldrich

Silica, mesoporous, 2 μm particle size, pore size ~4 nm

806862

Sigma-Aldrich

Silica, mesoporous SBA-15, <150 μm particle size, pore size 6 nm, Hexagonal pore morphology

806927

Sigma-Aldrich

Silica, mesoporous SBA-16, <150 μm particle size, pore size 5 nm, Cubic pore morphology

806951

Sigma-Aldrich

Silica, mesoporous, 3 μm particle size, pore size ~4 nm

914878

Sigma-Aldrich

Silica, mesoporous, 200 nm particle size, pore size ~2 nm

808989

Sigma-Aldrich

Silica, mesoporous, 0.5 μm particle size, pore size ~4 nm

806765

Sigma-Aldrich

Silica, mesoporous, 3 μm particle size, pore size ~2 nm

806587

Sigma-Aldrich

Silica, mesoporous, 2 μm particle size, pore size ~2 nm

805467

Sigma-Aldrich

Silica, mesoporous MCM-48, ≤15 μm particle size, pore size 3 nm, Cubic pore morphology

420816

Sigma-Aldrich

LUDOX^® HS-40 colloidal silica, 40 wt. % suspension in H₂O

420840

Sigma-Aldrich

LUDOX^® AS-40 colloidal silica, 40 wt. % suspension in H₂O

420778

Sigma-Aldrich

LUDOX^® TM-50 colloidal silica, 50 wt. % suspension in H₂O