- Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders.
Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders.
Journal of inorganic biochemistry (2011-11-22)
Joseph Lemire, Vasu D Appanna
PMID22099161
ABSTRACT
Aluminum (Al) has been implicated in a variety of neurological diseases. However, the molecular mechanisms that enable Al to be involved in these disorders have yet to be fully delineated. Using astrocytes as a model of the cerebral cellular system, we have uncovered the biochemical networks that are affected by Al toxicity. In this review, we reveal how the inhibitory influence of Al on ATP production and on mitochondrial functions help generate globular astrocytes that are fat producing machines. These biological events may be the contributing factors to Al-triggered brain disorders.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Aluminum, evaporation slug, diam. × L 6.3 mm × 6.3 mm, 99.999% trace metals basis
Aluminum, IRMM®, certified reference material, 1.0 mm foil
Aluminum, IRMM®, certified reference material, 1.0 mm wire
Aluminum, wire reel, 5m, diameter 2.0mm, as drawn, 99.999%
Aluminum, wire reel, 5m, diameter 3.0mm, as drawn, 99.999%
Aluminum, sphere, 100pcs, diameter 3.0mm, aluminum alloy 2017 precision sphere, grade 200, 95.2%
Aluminum, rod, 200mm, diameter 20.0mm, as drawn, 99.999%
Aluminum, rod, 100mm, diameter 28mm, as drawn, 99.999%
Aluminum, wire reel, 100m, diameter 0.25mm, hard, 99.99+%
Aluminum, wire reel, 1000m, diameter 0.30mm, as drawn, 99.5%
Aluminum, wire reel, 100m, diameter 0.063mm, annealed, 99.99%
Aluminum, wire reel, 20m, diameter 0.7mm, as drawn, 99.5%
Aluminum, wire reel, 10m, diameter 0.025mm, as drawn, 99.0+%
Aluminum, wire reel, 1m, diameter 0.025mm, as drawn, 99.99+%
Aluminum, wire reel, 10m, diameter 0.125mm, as drawn, 99.5%
Aluminum, wire reel, 20m, diameter 0.063mm, annealed, 99.99%
Aluminum, mesh, 150x150mm, nominal aperture 0.38mm, wire diameter 0.25mm, 40x40 wires/inch, open area 37%, plain weave mesh
Aluminum, microleaf disks, 10mm, thinness 1.0μm, specific density 269.9μg/cm2, removable support, 99.999%
Aluminum, rod, 50mm, diameter 28mm, as drawn, 99.999%
Aluminum, microfoil, disks, 25mm, thinness 1.0μm, specific density 269.9μg/cm2, permanent mylar 3.5μm support, 99.999%
Aluminum, microleaf disks, 25mm, thinness 0.15μm, specific density 41.28μg/cm2, removable support, 99.999%
Aluminum, rod, 500mm, diameter 5.0mm, as drawn, 99.999%
Aluminum, tube, 0.5m coil, as drawn, outside diameter 0.30mm, inside diameter 0.2mm, wall thickness 0.05mm, 99.5%
Aluminum, rod, 100mm, diameter 12.0mm, as drawn, 99.999%
Aluminum, rod, 500mm, diameter 15.0mm, as drawn, 99.999%