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  • Alkaline citrate reduces stone recurrence and regrowth after shockwave lithotripsy and percutaneous nephrolithotomy.

Alkaline citrate reduces stone recurrence and regrowth after shockwave lithotripsy and percutaneous nephrolithotomy.

International braz j urol : official journal of the Brazilian Society of Urology (2011-11-22)
B Lojanapiwat, M Tanthanuch, C Pripathanont, S Ratchanon, S Srinualnad, T Taweemonkongsap, S Kanyok, S Lammongkolkul
ABSTRACT

To evaluate the preventive effects of alkaline citrate on stone recurrence as well as stone growth post-ESWL or PCNL in patients with calcium-containing stones. A total of 76 patients with calcium calculi who were stone-free or had residual stones less than 4 mm following ESWL and PCNL were enrolled. All patients were independently randomized into two groups. The treated group (N = 39) was given 81 mEq per day of oral potassium-sodium citrate (27 mEq three times a day), and the untreated group (N = 37) serving as controls. Blood, twenty-four hour urine analysis, and plain KUB were measured and compared at the baseline and after 12 months. At baseline, hypocitraturia was found in 20 of 39 patients (46.05%) of Group I and 15 of 37 patients (40.5%) of Group II. At 12 months, hypocitraturia was found in 3 of 39 (7.69%) and 14 of 37 (37.83%) of Group I and Group II, respectively (p = 0.007). At the 12 month follow-up, of the stone-free group, 92.3% of the treated group and 57.7% of the control group were still stone free. Of the residual stone group, 30.8% and 9.1% of treated and control group were stone-free, respectively. The increased stone size found in 7.7%) and 54.5%) of treated and control groups, respectively. Sodium-potassium citrate provides positive effects on stone-forming activities in calcium stone patients suffering from urolithiasis following treatment with ESWL and PCNL procedures at the 12-month follow-up.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Potassium citrate tribasic monohydrate, purum p.a., ≥99.0% (NT)
Sigma-Aldrich
Potassium citrate tribasic monohydrate, meets USP testing specifications
Sigma-Aldrich
Potassium citrate tribasic monohydrate, ≥98% (GC/titration)
Sigma-Aldrich
Potassium citrate tribasic monohydrate, suitable for cell culture
Sigma-Aldrich
Potassium citrate tribasic monohydrate, meets analytical specification of Ph. Eur., BP, FCC, E332, 99-100.5% (calc with ref. to anhyd. subst.)