- Specific stabilization of DNA triple helices by indolo[2,1-b]quinazolin-6,12-dione derivatives.
Specific stabilization of DNA triple helices by indolo[2,1-b]quinazolin-6,12-dione derivatives.
Bioorganic & medicinal chemistry letters (2007-01-24)
Grace Shiahuy Chen, Bhalchandra V Bhagwat, Pei-Yin Liao, Hui-Ting Chen, Shwu-Bin Lin, Ji-Wang Chern
PMID17239588
ABSTRACT
Derivatives of indolo[2,1-b]quinazolinone containing aminoalkylamino side chains were synthesized as specific DNA triplex stabilizing agents. The aminoalkylamino side chains are essential for triplex stabilization. The position-8 fluorine atom or a methyl group to the nitrogen adjacent to the planar core can enhance triplex stability by 6 degrees C and the effect is additive. Conformational analysis reveals that the orientation of the side chain underlies the ability of this compound to stabilize a DNA triplex.
MATERIALS