S1437
Sex Hormone-Binding Globulin from human serum
≥95% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
SHBG, Testosterone-estradiol binding globulin
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About This Item
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biological source
human serum
Quality Level
Assay
≥95% (SDS-PAGE)
form
buffered aqueous glycerol solution
technique(s)
cell culture | mammalian: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... SHBG(6462)
General description
Sex hormone binding globulin (SHBG) is secreted by the liver. It is also expressed in the endometrium, ovary and testis. SHBG is composed of 402 amino acids and the gene encoding it is localized on human chromosome 17p12–p13.
Application
Sex hormone binding globulin (SHBG) from human serum has been used as a spiked sample in radioimmunoassay. It may also be used to study the effects of hydroxylated estrogen metabolites (2-OH-E2 and 4-OH-E2) on the mRNA and protein expression of SHBG in MCF-7 human breast cancer cell line.
Biochem/physiol Actions
Sex hormone binding globulin (SHBG) is a dimeric plasma glycoprotein with high affinity for the gonadal steroids, testosterone and estradiol. It regulates the availability of sex steroid hormones and limits their access to target cells. SHBG also inhibits estradiol-induced proliferation of breast cancer cells. Alterations in the expression of the protein have been linked to male infertility.
Physical form
Solution in 20 mM Tris-HCl, 10% Glycerol, pH 7.4
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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The ability of hydroxylated estrogens (2-OH-E2 and 4-OH-E2) to increase
of SHBG gene, protein expression and intracellular levels in MCF-7 cells
line
of SHBG gene, protein expression and intracellular levels in MCF-7 cells
line
Gregoraszczuk EL
Endocrine regulations (2011)
Sex Hormone-Binding Globulin (SHBG), estradiol and breast cancer.
Fortunati N
Molecular and Cellular Endocrinology (2010)
Developmental time course of estradiol, testosterone, and dihydrotestosterone levels in discrete regions of male and female rat brain
Konkle ATM and McCarthy MM
Endocrinology, 152(1), 223-235 (2011)
Correlation between SHBG gene polymorphism and male infertility in Han population of Henan province of China
A STROBE-compliant article
A STROBE-compliant article
Yuan-rong Cui
Medicine (2017)
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