G117

Glipizide

solid

• Synonym(s): 1-Cyclohexyl-3-{4-[2-(5-methylpyrazine-2-carboxamido)ethyl]phenylsulfonyl}urea
• Empirical Formula (Hill Notation): C₂₁H₂₇N₅O₄S
• CAS Number: 29094-61-9
• Molecular Weight: 445.54
• EC Number: 249-427-6
• MDL number: MFCD00072159
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277839
• NACRES: NA.77

Properties

• form: solid
• color: white
• solubility: methanol: 1.9 mg/mL; DMSO: 48 mg/mL
• SMILES string: Cc1cnc(cn1)C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3
• InChI: 1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28)
• InChI key: ZJJXGWJIGJFDTL-UHFFFAOYSA-N
• Gene Information: human ... ABCC8(6833) , KCNJ1(3758) , KCNJ11(3767)

Description

General description

Potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1) codes for a renal outer medullary potassium channel (ROMK1, Kir1.1). Glipizide is an antidiabetic drug, that is used to treat type II diabetes.(5)

Application

Glipizide has been used in:

• chick embryo yolk sac membrane (YSM) and chorioallantoic membrane (CAM) assay
• MCF-7 breast cancer assay on chorioallantoic membrane (CAM)
• metastasis assays
• rat aortic ring assay
• in vivo matrigel plug assay
• 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay
• flow cytometry
• western blotting

Biochem/physiol Actions

Potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1) plays a vital role in potassium balance. It is an ATP-dependent K⁺ channel blocker. The encoded protein is liable for the elimination of potassium in exchange for the absorption of sodium by the epithelial sodium channel (ENaC). Mutation in KCNJ1 is linked with several diseases, such as, antenatal Bartter syndrome and diabetes. Glipizide helps to repress the development of tumors and metastasis by preventing angiogenesis.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves