Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

253421

Sigma-Aldrich

3-(2-Iodoacetamido)-PROXYL

free radical

Synonym(s):

3-(2-Iodoacetamido)-2,2,5,5-tetramethyl-1-pyrrolidinyloxy, free radical

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C10H18IN2O2
CAS Number:
27048-01-7
Molecular Weight:
325.17
MDL number:
MFCD00010161
UNSPSC Code:
12352101
PubChem Substance ID:
24855311
NACRES:
NA.22

form

solid

mp

162-164 °C (lit.)

storage temp.

2-8°C

SMILES string

CC1(C)CC(NC(=O)CI)C(C)(C)N1[O]

InChI

1S/C10H18IN2O2/c1-9(2)5-7(12-8(14)6-11)10(3,4)13(9)15/h7H,5-6H2,1-4H3,(H,12,14)

InChI key

OQIGMSGDHDTSFA-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

3-(2-Iodoacetamido)-PROXYL is a free radical used as a spin probe in spin labeling techniques. This technique is helpful in investigating the dynamic aspects of molecular interactions of substances, proteins, lipids, and cell membranes.

Application

Sulfhydryl group specific spin label. Applications include study of ozone-treated human and bovine erythrocyte membrane proteins and the orientation of myosin subfragment on muscle fibers. DNA fragments containing phosphorothioate diesters can be labeled by spin labels.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 3

1 of 3

4-Oxo-TEMPO

Sigma-Aldrich

179485

4-Oxo-TEMPO

4-Hydroxy-TEMPO 95%

Sigma-Aldrich

176141

4-Hydroxy-TEMPO

TEMPO 98%

Sigma-Aldrich

214000

TEMPO

Na Li et al.
Scientific reports, 10(1), 393-393 (2020-01-17)
Fowlpox virus resolvase (Fpr) is an endonuclease that cleaves a broad range of branched DNA structures, including the Holliday junction (HJ), with little sequence-specificity. To better understand the mechanisms underlying its relaxed substrate specificity, we determined the crystal structures of
Christoph Gmeiner et al.
Physical chemistry chemical physics : PCCP, 19(41), 28360-28380 (2017-10-17)
A combined method, employing NMR and EPR spectroscopies, has demonstrated its strength in solving structures of protein/RNA and other types of biomolecular complexes. This method works particularly well when the large biomolecular complex consists of a limited number of rigid
Tara L Kirby et al.
Biochemistry, 43(19), 5842-5852 (2004-05-12)
We used EPR spectroscopy to probe directly the interaction between phospholamban (PLB) and its regulatory target, the sarcoplasmic reticulum Ca-ATPase (SERCA). Synthetic monomeric PLB was prepared with a single cytoplasmic cysteine at residue 11, which was then spin labeled. PLB
Anna I Nalepa et al.
Protein expression and purification, 88(1), 33-40 (2012-12-04)
α(1)-Microglobulin (α(1)m) is a protein of yet unresolved function occurring in blood plasma and urine. It consists of a lipocaline type of fold with two cysteine residues forming a disulfide bridge and the third cysteine-34 remaining a free, somewhat reactive
C J Penington et al.
Biochemistry, 31(11), 2912-2920 (1992-03-24)
The substrate-binding site of a human muscle class mu glutathione transferase has been characterized using high-resolution nuclear magnetic resonance spectroscopy. Isotopic labeling has been used to simplify one-dimensional proton NMR spectra of the Tyr and His residues in the enzyme
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service