Nitration of MOG diminishes its encephalitogenicity depending on MHC haplotype.

Nitration of MOG diminishes its encephalitogenicity depending on MHC haplotype.

Journal of neuroimmunology (2016-12-25)

Andreas Warnecke, Sravani Musunuri, Marie N'diaye, Tatyana Sandalova, Adnane Achour, Jonas Bergquist, Robert A Harris

초록

Post-translational modifications of autoantigens are hypothesized to affect their immunogenicity. We here report that nitration of tyrosine 40 in Myelin Oligodendrocyte Glycoprotein (MOG) abrogates its encephalitogenicity both at protein and peptide levels in the experimental autoimmune encephalomyelitis (EAE) model in H2

MATERIALS

제품 번호

브랜드

제품 설명

N0409

Sigma-Aldrich

Anti-Nitrotyrosine antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution